WSJ’s The Future of Everything

How does your doctor know that a drug or procedure will work to treat a condition before they try it? Often, they don’t. Researchers are looking to create “digital twins,” digital versions of individual organs, to see how a patient will respond. Eventually there could be digital twins of entire bodies that are updated in real time with patient data. WSJ’s Alex Ossola speaks with WSJ senior special writer Stephanie Armour about how that might change the way we treat diseases in the future.  What do you think about the show? Let us know on Apple Podcasts [https://podcasts.apple.com/us/podcast/wsjs-the-future-of-everything/id1234320525] or Spotify [https://open.spotify.com/show/2KICk2MxwEn9csPnvDQt6Q] , or email us: FOEPodcast@wsj.com [FOEPodcast@wsj.com]  Sign up for the WSJ's free The Future of Everything newsletter [https://www.wsj.com/newsletters/the-future-of-everything?mod=WSJ_FOEPOD].  Further reading: A ‘Digital Twin’ of Your Heart Lets Doctors Test Treatments Before Surgery [https://www.wsj.com/health/healthcare/digital-heart-surgery-patient-treatment-c35ec4be]   Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

Ultrasound is known for its use in imaging during pregnancy. But new advancements in the technology suggest that in the future, ultrasound could be used to disrupt the blood-brain barrier. This would allow doctors to more easily diagnose and directly treat illnesses like brain cancer without major surgery. WSJ’s Danny Lewis and Charlotte Gartenberg examine the new ways that ultrasound could be used more specifically and subtly to deliver accurate diagnoses and precise treatments. What do you think about the show? Let us know on Apple Podcasts [https://podcasts.apple.com/us/podcast/wsjs-the-future-of-everything/id1234320525] or Spotify [https://open.spotify.com/show/2KICk2MxwEn9csPnvDQt6Q], or email us: FOEPodcast@wsj.com [FOEPodcast@wsj.com] Sign up for the WSJ's free The Future of Everything newsletter [https://www.wsj.com/newsletters/the-future-of-everything?mod=WSJ_FOEPOD] . Further reading: New Ultrasound Therapy Could Help Treat Alzheimer’s, Cancer [https://www.wsj.com/articles/ultrasound-therapy-alzheimers-cancer-treatment-862f1390?st=l0zu0noz65jdyyh&reflink=desktopwebshare_permalink]  Treatment Breakthrough for an Intractable Brain Cancer [https://www.wsj.com/articles/treatment-breakthrough-for-an-intractable-brain-cancer-138402b9?st=4hczi1ez1jfzmqe&reflink=desktopwebshare_permalink]  The ‘Mini Brains’ solving medical mysteries and raising concerns [https://www.wsj.com/podcasts/wsj-the-future-of-everything/the-mini-brains-solving-medical-mysteries-and-raising-concerns/8681f7dd-8414-4175-90b9-477f33f434d3] We Can Now See the Brain Like Never Before [https://www.wsj.com/science/brain-mapproject-neuroscience-b0f90b02?st=e9sqyh1havpnmyb&reflink=desktopwebshare_permalink]  Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

A day when people can interact directly with computers using their thoughts could be on the horizon. Several companies, including Elon Musk’s Neuralink, have begun preliminary human trials of brain-computer interfaces - devices that decode the electrical signals in their brain and translate them into digital bits. Neurosurgeon Benjamin Rapoport is a co-founder and chief science officer of Precision Neuroscience, a company working on brain-computer interfaces. He spoke with WSJ’s Danny Lewis about how the technology works and how these implants could improve the lives of hundreds of thousands of people who could gain the ability to independently engage with the digital world. Correction: Dr. Benjamin Rapoport is the co-founder of Precision Neuroscience. An earlier version misspelled his name Rapaport. (Corrected on May 3) What do you think about the show? Let us know on Apple Podcasts [https://podcasts.apple.com/us/podcast/wsjs-the-future-of-everything/id1234320525] or Spotify [https://open.spotify.com/show/2KICk2MxwEn9csPnvDQt6Q], or email us: FOEPodcast@wsj.com [https://open.spotify.com/show/2KICk2MxwEn9csPnvDQt6Q]  Further reading: Inside the Operating Room: Doctors Test a Revolutionary Brain-Computer Implant [https://www.wsj.com/science/inside-the-operating-room-doctors-test-a-revolutionary-brain-computer-implant-f69eb0c2?st=ziadjrofvundu0q&reflink=desktopwebshare_permalink]  Elon Musk’s Neuralink Wants to Make ‘The Matrix’ a Reality. It Has a Lot to Prove First. [https://www.wsj.com/tech/biotech/elon-musk-neuralink-brain-chip-research-2235b897?st=uuizia29iopjrei&reflink=desktopwebshare_permalink]  She Didn’t Speak for 18 Years. A Computer Helped Find Her Voice. [She%20Didn%E2%80%99t%20Speak%20for%2018%20Years.%20A%20Computer%20Helped%20Find%20Her%20Voice.]  The Devices That Will Read Your Brain—and Enhance It [The%20Devices%20That%20Will%20Read%20Your%20Brain%E2%80%94and%20Enhance%20It]  Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

What does the brick and mortar bookstore of the future look like? For Barnes & Noble, it looks more like the indie bookstores they once threatened to put out of business 20 years ago. The company recently redesigned their national chain of over 500 bookstores, shedding the big box personality in favor of a look reminiscent of local bookshops. On this week’s Science of Success, WSJ columnist Ben Cohen speaks to Barnes & Noble CEO James Daunt about the look, feel and idea behind Barnes & Noble’s new indie design. What do you think about the show? Let us know on Apple Podcasts [https://podcasts.apple.com/us/podcast/wsjs-the-future-of-everything/id1234320525] or Spotify [https://open.spotify.com/show/2KICk2MxwEn9csPnvDQt6Q], or email us: FOEPodcast@wsj.com [FOEPodcast@wsj.com]  Listening on Google Podcasts? Here's our guide [https://www.wsj.com/tech/google-podcasts-e100656c?st=0q6q77a4arjdc9p&reflink=desktopwebshare_permalink] for switching to a different podcast player. Further reading: That Cool New Bookstore? It’s a Barnes & Noble. [https://www.wsj.com/articles/barnes-noble-bookstores-james-daunt-c1afc06b] New CEO Wants to Make Barnes & Noble Your Local Bookstore [https://www.wsj.com/articles/british-bookseller-plots-turnaround-at-barnes-noble-11565258401?mod=searchresults&page=1&pos=2&mod=article_inline] Barnes & Noble’s New Boss Tries to Save the Chain—and Traditional Bookselling [https://www.wsj.com/articles/barnes-nobles-new-boss-tries-to-save-the-chainand-traditional-bookselling-11607144485?mod=article_inlinehttps://www.wsj.com/articles/barnes-nobles-new-boss-tries-to-save-the-chainand-traditional-bookselling-11607144485?mod=article_inline]  Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

Can technology help us design the perfect running shoe that’s stronger, faster and better for the environment? David Allemann [https://investors.on-running.com/governance/board-of-directors/person-details/default.aspx?ItemId=dcee1bb1-ba8c-44af-8e7d-a33ed8452efb], co-founder of On, thinks technology can get us part of the way there, but it’s not the whole story. The performance running shoe and sportswear company is experimenting with computer simulation and bio-based materials to design sneakers to advance both runners and sustainability goals. WSJ men’s fashion columnist Jacob Gallagher speaks with Allemann about the future of running shoe tech and how sneakers might redefine the design cannon.  What do you think about the show? Let us know on Apple Podcasts [https://podcasts.apple.com/us/podcast/wsjs-the-future-of-everything/id1234320525] or Spotify [https://open.spotify.com/show/2KICk2MxwEn9csPnvDQt6Q], or email us: FOEPodcast@wsj.com [FOEPodcast@wsj.com]  Further reading:  How On’s Running Sneakers Won Over Tech Bros and High Fashion Alike [https://www.wsj.com/articles/on-running-sneakers-cloudmonster-11648642860]  Where Did All the Crazy Sneakers Go? [https://www.wsj.com/style/fashion/sneaker-industry-sambas-adidas-jordan-nike-c8ed16b3]  This Designer Knows What Sneakers You’ll Be Wearing Next Year [https://www.wsj.com/style/fashion/salehe-bembury-crocs-versace-sneakers-2d99c434]  These Grandpa Sneakers Are Made in America. They’re a Hit Overseas. [https://www.wsj.com/articles/san-antonio-shoemakers-sneakers-78bf202]  Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]